Quick Reference
- Scientific Rating
-
4.8/ 5.0
- Primary Mechanism
- Adaptogenic / Homeostasis
- Standardized Form
- Root extract, usually standardized to ≥ 5% withanolides
Ashwagandha (Withania somnifera) is a root extract long used in Ayurvedic medicine as an adaptogen, a class of botanicals traditionally associated with helping the body regulate its response to physical and mental stress. Modern research points to modulation of the hypothalamic-pituitary-adrenal (HPA) axis, the system that governs cortisol release, as its primary mechanism of action. This has made high-concentration root extract, standardized for withanolide content, one of the most widely studied adaptogens in contemporary stress-support formulas.
Table of Contents
Clinical Summary
Current scientific literature robustly supports Ashwagandha for stress and anxiety reduction. Multiple double-blind, placebo-controlled trials show significant reductions in serum cortisol levels.
Dosage Guidelines
Standard clinical dosages vary between 300mg to 600mg daily of a high-concentration full-spectrum root extract (such as KSM-66).
Safety & Side Effects
Generally considered safe for most healthy adults. Mild gastrointestinal upset, diarrhea, or nausea may occur in rare cases.
Known Interactions
May interact with immunosuppressants, sedatives, and thyroid hormone medications. Always consult your physician.
Scientific References
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Medical Disclaimer
The information provided in this clinical review is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
*These statements have not been evaluated by the Food and Drug Administration (FDA). This product or ingredient is not intended to diagnose, treat, cure, or prevent any disease.
Always consult your physician or other qualified health provider with any questions you may have regarding a medical condition, or before beginning any new diet, fitness, supplement, or treatment regimen, especially if you have pre-existing medical conditions or are taking prescribed medications.
